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USC Favored to Dominate Week 0 Opener

No. 14 USC enters the 2026 season as a strong betting favorite against San Jose State in Week 0.

Week 0 of the 2026 college football season brings several betting opportunities. The North Carolina vs. TCU rematch in Dublin favors the Under 47.5, as both teams feature new quarterbacks and rainy weather is expected. Meanwhile, No. 14 USC is projected to dominate San Jose State, with odds favoring the Trojans to exceed their team total of 48.5 points and score at least seven touchdowns in their season opener.

In the NC State vs. Virginia matchup, NC State returns quarterback CJ Bailey with 53 career touchdowns, giving them an edge in a game expected to be close, similar to their 35-31 victory last September. Virginia loses significant production from quarterback Chandler Morris, making the Wolfpack a solid betting option with the points. playerbros.org